Document Detail

The cephalosporin compounds in severe neonatal infection.
MedLine Citation:
PMID:  6321189     Owner:  NLM     Status:  MEDLINE    
The new cephalosporin compounds have increased in vitro activity against gram-negative enteric bacilli and penetrate well into cerebrospinal fluid. Moreover, their pharmacokinetic properties are favorable and their safety seems adequate, although insufficiently evaluated to date. Interest has been focused on them as therapeutic agents for neonatal sepsis and meningitis caused by Enterobacteriaceae. In this review the third generation cephalosporins are evaluated for their possible use in the neonates; opinions are based on currently available data. It is concluded that moxalactam and cefotaxime and probably also ceftriaxone and ceftazidime represent valuable alternatives to aminoglycosides for therapy of severe neonatal infection.
U B Schaad
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of pediatrics     Volume:  141     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-04-18     Completed Date:  1984-04-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  143-6     Citation Subset:  IM    
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MeSH Terms
Cefotaxime / analogs & derivatives,  therapeutic use
Cephalosporins / therapeutic use*
Enterobacteriaceae Infections / drug therapy*
Infant, Newborn
Meningitis / drug therapy
Moxalactam / therapeutic use
Sepsis / drug therapy
Reg. No./Substance:
0/Cephalosporins; 63527-52-6/Cefotaxime; 64952-97-2/Moxalactam; 73384-59-5/Ceftriaxone; 78439-06-2/Ceftazidime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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