| The cephalic neural crest of amniote vertebrates is composed of a large majority of precursors endowed with neural, melanocytic, chondrogenic and osteogenic potentialities. | |
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MedLine Citation:
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PMID: 20037475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the amniote embryo, the neural crest (NC) has the unique capacity to give rise to neuronal and glial cells in the peripheral nervous system (PNS), melanocytes and mesenchymal cells including those forming the head skeleton and connective tissues. In the trunk, mesenchymal cells are derived from the mesoderm. The question was raised whether the NC-derived head mesenchyme arises from a lineage separate from the neural-melanocytic one, or if both skeletogenic and neural-melanocytic derivatives originate from a common putative stem cell in the early cephalic NC. We discuss here these issues and present experimental data that provide evidence for the multipotency of NC cells (NCC), focusing on those at the origin of the craniofacial skeleton. Recent work of in vitro clonal culture revealed that the vast majority (92% of clonogenic cells) of the cephalic quail NCC are capable to yield osteoblasts together with neurones, glial cells and melanocytes. A common pluripotent progenitor for chondrocytes, osteocytes, neurones, glial cells, melanocytes and myofibroblasts has been identified and is present in the early cephalic NC at the frequency of 7 to 13% of clonogenic cells depending on the environmental conditions. Together with recent reports that multipotent NC-related progenitors persist in adult tissues in rodents and humans, these results reinforce a stem cell model for the generation and maintenance of NC-derived lineages during embryogenesis and in adult tissue homeostasis. |
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Authors:
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Elisabeth Dupin; Giordano W Calloni; Nicole M Le Douarin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-01-26 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 9 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-22 Completed Date: 2010-04-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 238-49 Citation Subset: IM |
Affiliation:
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CNRS UPR2197 Laboratoire D?veloppement, Evolution et Plasticit? du Syst?me Nerveux, Institut de Neurobiologie Alfred Fessard, Gif-sur-Yvette, France. dupin@inaf.cnrs-gif.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation Chondrocytes / cytology Core Binding Factor Alpha 1 Subunit / metabolism Embryonic Development Hedgehog Proteins / metabolism Melanocytes / cytology Multipotent Stem Cells / cytology*, metabolism Neural Crest / cytology*, metabolism Neuroglia / cytology Neurons / cytology Osteoblasts / cytology Vertebrates / embryology |
| Chemical | |
Reg. No./Substance:
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0/Core Binding Factor Alpha 1 Subunit; 0/Hedgehog Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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