Document Detail

The central vein access port and catheter in outpatient chemotherapy for colorectal cancer: a retrospective study of 101 patients.
MedLine Citation:
PMID:  22105529     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The central venous access port (CV-port) system was examined in a series of colorectal cancer (CRC) patients.
METHODS: One hundred and one CRC patients underwent chemotherapy with the 5-fluorouracil + oxaliplatin (FOLFOX) or 5-fluorouracil + irinotecan regimen. The complications of the CV-port system were retrospectively assessed.
RESULTS: The CV-port system was placed in a total of 101 patients. The patients received a total of 1020 [corrected] courses of these regimens. Eight complications occurred in the 101 patients (7.9%). The complications included three instances of catheter rupture, two thrombotic events around the catheter, and three infections at the site of the port or catheter. The complications were identified after a median of nine courses (range 6-16) and 135 days after the placement of the CV-port system. Sixty-six of the 101 patients switched their regimen from FOLFOX to another regimen, and 4 of these 66 patients (6.1%) experienced complications associated with the CV-port system. There were 25 subjects who were admitted to the hospital emergency wing during the chemotherapeutic regimens, and 4 of these patients (16%) had complications associated with the CV-port system.
CONCLUSIONS: The complications of the CV-port system occurred at a defined rate, therefore the early diagnosis and the appropriate treatment to address these complications is crucial.
Hiroshi Sawayama; Naoko Hayashi; Masayuki Watanabe; Hiroshi Takamori; Toru Beppu; Hideo Baba
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Publication Detail:
Type:  Journal Article     Date:  2011-11-22
Journal Detail:
Title:  Surgery today     Volume:  42     ISSN:  1436-2813     ISO Abbreviation:  Surg. Today     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-09     Completed Date:  2012-05-04     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  29-34     Citation Subset:  IM    
Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.
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MeSH Terms
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
Camptothecin / administration & dosage,  analogs & derivatives
Catheterization, Central Venous / adverse effects*
Colorectal Neoplasms / drug therapy*
Fluorouracil / administration & dosage
Middle Aged
Organoplatinum Compounds / administration & dosage
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Organoplatinum Compounds; 51-21-8/Fluorouracil; 58-05-9/Leucovorin; 63121-00-6/oxaliplatin; 7673326042/irinotecan; 7689-03-4/Camptothecin
Erratum In:
Surg Today. 2013 May;43(5):586

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