Document Detail


The central termination of sensory fibers from nerves to the gastrocnemius muscle of the rat.
MedLine Citation:
PMID:  15953682     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peripheral nerves innervating muscles have sensory fibers that relay information into the CNS information about proprioception, pain, and the metabolic state of the muscle. The present study shows the primary afferent projections into the spinal cord of the nerves innervating the gastrocnemius muscle of the rat using the transganglionic transport of a cocktail of horseradish peroxidase (HRP) conjugated to cholera toxin and wheat germ agglutinin; these markers have been shown to label large and small fibers, respectively. A dense projection into lamina I of the lumbar dorsal horn and a more moderate projection into lamina V were seen. Moreover, dense reaction product was found in the most medial aspect of lamina II, especially lamina II inner part, and less in lamina III and IV of levels L3-L5. Lamina VI had dense reaction product from the rostral sacral levels of the spinal cord that continued into Clarke's column at rostral lumbar levels. The nucleus gracilis also was labeled. Other nerves emerging from the popliteal fossa, including the tibial, peroneal, and sural nerves, also were injected with the HRP cocktail and their projections compared with those from the gastrocnemius muscle. Projections from the gastrocnemius muscle only partially overlapped with those from the tibial nerve, from which the nerves to the gastrocnemius muscle branch. However, the topology of projections from these nerves to laminae II-IV of the dorsal horn differed from that of the nerves of the gastrocnemius muscle, suggesting there was little spread to other nerves in the popliteal fossa. It was also noted that large labeled processes, presumably dendrites of retrogradely labeled motoneurons, entered the dorsal horn. These data provide information on the central projections of both the large and small fibers innervating the gastrocnemius muscle, and may aid in determining the circuitry utilized in the exercise pressor reflex as well as muscle pain.
Authors:
W M Panneton; Q Gan; R Juric
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience     Volume:  134     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  2005  
Date Detail:
Created Date:  2005-07-11     Completed Date:  2005-12-02     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  175-87     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Afferent Pathways / anatomy & histology*
Animals
Male
Motor Neurons / cytology*
Muscle, Skeletal / innervation*
Posterior Horn Cells / cytology
Rats
Rats, Sprague-Dawley
Spinal Cord / cytology*
Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate / metabolism
Grant Support
ID/Acronym/Agency:
HL 64772/HL/NHLBI NIH HHS; R01 HL064772/HL/NHLBI NIH HHS; R01 HL064772-02/HL/NHLBI NIH HHS; R01 HL064772-03/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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