Document Detail

The central role of Sertoli cells in spermatogenesis.
MedLine Citation:
PMID:  9813187     Owner:  NLM     Status:  MEDLINE    
Sertoli cells are the somatic cells of the testis that are essential for testis formation and spermatogenesis. Sertoli cells facilitate the progression of germ cells to spermatozoa via direct contact and by controlling the environment milieu within the seminiferous tubules. The regulation of spermatogenesis by FSH and testosterone occurs by the action of these hormones on the Sertoli cells. While the action of testosterone is necessary for spermatogenesis, the action of FSH minimally serves to promote spermatogenic output by increasing the number of Sertoli cells.
M D Griswold
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  9     ISSN:  1084-9521     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1999-06-07     Completed Date:  1999-06-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  411-6     Citation Subset:  IM    
Copyright Information:
Copyright 1998 Academic Press.
Department of Biochemistry and Biophysics, Washington State University, Pullman, WA, 99164-4660, USA.
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MeSH Terms
Sertoli Cells / cytology*,  physiology*
Spermatogenesis / physiology*
Comment In:
Semin Cell Dev Biol. 1998 Aug;9(4):379-91   [PMID:  9813185 ]

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