Document Detail


The central nervous system and inflammation in hypertension.
MedLine Citation:
PMID:  21196131     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In recent years a major research effort has focused on the role of inflammation, and in particular adaptive immunity, in the genesis of hypertension. Hypertension stimulates the accumulation of inflammatory cells including macrophages and T lymphocytes in peripheral tissues important in blood pressure control, such as the kidney and vasculature. Angiotensin II modulates blood pressure via actions on the central nervous system (CNS) and the adaptive immune system. Recent work suggests that the central actions of angiotensin II via the circumventricular organs lead to activation of circulating T-cells and vascular inflammation. The neuro-immune system plays an essential role in the pathogenesis of hypertension and further understanding of this relationship could lead to the development of new treatment strategies.
Authors:
Paul J Marvar; Heinrich Lob; Antony Vinh; Faresa Zarreen; David G Harrison
Publication Detail:
Type:  Journal Article; Review     Date:  2010-12-31
Journal Detail:
Title:  Current opinion in pharmacology     Volume:  11     ISSN:  1471-4973     ISO Abbreviation:  Curr Opin Pharmacol     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-12     Completed Date:  2011-08-05     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  100966133     Medline TA:  Curr Opin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  156-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adaptive Immunity
Angiotensin II / physiology
Animals
Brain / physiology*
Humans
Hypertension / etiology*
Immune System / physiology
Inflammation / complications*
Lymphocyte Activation
Renin-Angiotensin System / physiology
T-Lymphocytes / immunology
Grant Support
ID/Acronym/Agency:
F32 DK080575-01/DK/NIDDK NIH HHS; F32 DK080575-02/DK/NIDDK NIH HHS; P01 HL058000/HL/NHLBI NIH HHS; P01 HL058000-10/HL/NHLBI NIH HHS; R01 HL039006/HL/NHLBI NIH HHS; R01 HL039006-23/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
11128-99-7/Angiotensin II
Comments/Corrections

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