Document Detail


The central nervous system at the core of the regulation of energy homeostasis.
MedLine Citation:
PMID:  19482713     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Energy homeostasis is kept through a complex interplay of nutritional, neuronal and hormonal inputs that are integrated at the level of the central nervous system (CNS). A disruption of this regulation gives rise to life-threatening conditions that include obesity and type-2 diabetes, pathologies that are strongly linked epidemiologically and experimentally. The hypothalamus is a key integrator of nutrient-induced signals of hunger and satiety, crucial for processing information regarding energy stores and food availability. Much effort has been focused on the identification of hypothalamic pathways that control food intake but, until now, little attention has been given to a potential role for the hypothalamus in direct control of glucose homeostasis. Recent studies have cast a new light on the role of the CNS in regulating peripheral glucose via a hypothalamic lipid-sensing device that detects nutrient availability and relays, through the autonomic nervous system, a negative feedback signal on food intake, insulin sensitivity and insulin secretion. This review aims to summarize recent discoveries that highlight the brain as a potential target for anti-diabetic strategies.
Authors:
Serge Luquet; Christophe Magnan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-06-01
Journal Detail:
Title:  Frontiers in bioscience (Scholar edition)     Volume:  1     ISSN:  1945-0524     ISO Abbreviation:  Front Biosci (Schol Ed)     Publication Date:  2009  
Date Detail:
Created Date:  2009-06-01     Completed Date:  2010-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485241     Medline TA:  Front Biosci (Schol Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  448-65     Citation Subset:  IM    
Affiliation:
University Paris Diderot-Paris 7-Unit of Functional and Adaptive Biology (BFA) EAC 7059C NRS, France.
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MeSH Terms
Descriptor/Qualifier:
Central Nervous System / metabolism,  physiology*
Dietary Proteins / administration & dosage
Energy Metabolism*
Glucose / metabolism
Homeostasis*
Humans
Insulin / metabolism
Intestines / metabolism
Leptin / metabolism
Nerve Net
Serotonin / physiology
Signal Transduction
Chemical
Reg. No./Substance:
0/Dietary Proteins; 0/Leptin; 11061-68-0/Insulin; 50-67-9/Serotonin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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