| The central insulin system and energy balance. | |
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MedLine Citation:
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PMID: 22249812 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Insulin acts throughout the body to reduce circulating energy and to increase energy storage. Within the brain, insulin produces a net catabolic effect by reducing food intake and increasing energy expenditure; this is evidenced by the hypophagia and increased brown adipose tissue sympathetic nerve activity induced by central insulin infusion. Reducing the activity of the brain insulin system via administration of insulin antibodies, receptor antisense treatment, or receptor knockdown results in hyperphagia and increased adiposity. However, despite decades of research into the role of central insulin in food intake, many questions remain to be answered, including the underlying mechanism of action. |
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Authors:
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Denovan P Begg; Stephen C Woods |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Handbook of experimental pharmacology Volume: 209 ISSN: 0171-2004 ISO Abbreviation: Handb Exp Pharmacol Publication Date: 2012 |
Date Detail:
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Created Date: 2012-01-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902231 Medline TA: Handb Exp Pharmacol Country: Germany |
Other Details:
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Languages: eng Pagination: 111-29 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH, 45237, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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