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The central effects of thyroid hormones on appetite.
MedLine Citation:
PMID:  21687648     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Obesity is a major public health issue worldwide. Current pharmacological treatments are largely unsuccessful. Determining the complex pathways that regulate food intake may aid the development of new treatments. The hypothalamic-pituitary-thyroid (HPT) axis has well-known effects on energy expenditure, but its role in the regulation of food intake is less well characterised. Evidence suggests that the HPT axis can directly influence food intake. Thyroid dysfunction can have clinically significant consequences on appetite and body weight. Classically, these effects were thought to be mediated by the peripheral effects of thyroid hormone. However, more recently, local regulation of thyroid hormone in the central nervous system (CNS) is thought to play an important role in physiologically regulating appetite. This paper focuses on the role of the HPT and thyroid hormone in appetite and provides evidence for potential new targets for anti-obesity agents.
Authors:
Anjali Amin; Waljit S Dhillo; Kevin G Murphy
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Publication Detail:
Type:  Journal Article     Date:  2011-05-25
Journal Detail:
Title:  Journal of thyroid research     Volume:  2011     ISSN:  2042-0072     ISO Abbreviation:  J Thyroid Res     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-20     Completed Date:  2011-07-14     Revised Date:  2011-08-01    
Medline Journal Info:
Nlm Unique ID:  101536655     Medline TA:  J Thyroid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  306510     Citation Subset:  -    
Affiliation:
Section of Investigative Medicine, Faculty of Medicine, Imperial College London, 6th Floor, Commonwealth Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
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