| The central action of 1-(2-pyrimidinyl)-piperazine, an ipsapirone metabolite. | |
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MedLine Citation:
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PMID: 2587437 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The central action of 1-(2-pyrimidinyl)-piperazine (1-PP), a metabolite of ipsapirone, was studied in mice and rats. 1-PP decreased the locomotor activity and slightly increased the body temperature at an ambient temperature of 21 degrees C, not changing it at an ambient temperature of 28 degrees C. The examined substance antagonized clonidine effects (hypothermia, locomotor hypoactivity, stimulation of the hind limb flexor reflex of the spinal rat). Stimulation of the flexor reflex by St 587, an alpha 1-adrenoceptor agonist was not blocked by 1-PP. 1-PP-induced stimulation of the flexor reflex was blocked by cyproheptadine, ketanserin and pirenperone, but not by prazosin or yohimbine. Given in high doses, 1-PP evoked a flat body posture syndrome, but not forepaw treading or head twitches. The obtained results indicate that 1-PP has mainly an alpha 2-adrenolytic action and differs from ipsapirone in its profile. |
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Authors:
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E Tatarczyńska; L Pawłowski; E Chojnacka-Wójcik; J Maj |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Polish journal of pharmacology and pharmacy Volume: 41 ISSN: 0301-0244 ISO Abbreviation: Pol J Pharmacol Pharm Publication Date: 1989 Jan-Feb |
Date Detail:
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Created Date: 1990-01-03 Completed Date: 1990-01-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0366561 Medline TA: Pol J Pharmacol Pharm Country: POLAND |
Other Details:
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Languages: eng Pagination: 51-61 Citation Subset: IM |
Affiliation:
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Institute of Pharmacology, Polish Academy of Sciences, Kraków. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature / drug effects Brain / drug effects*, physiology Buspirone / analogs & derivatives*, pharmacology Decerebrate State Hindlimb / physiology Male Mice Motor Activity / drug effects Pyrimidines / pharmacology* Rats Rats, Inbred Strains Reflex / drug effects Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/Pyrimidines; 20980-22-7/1-(2-pyrimidinyl)piperazine; 36505-84-7/Buspirone; 92589-98-5/ipsapirone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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