| The cementogenic differentiation of periodontal ligament cells via the activation of Wnt/β-catenin signalling pathway by Li(+) ions released from bioactive scaffolds. | |
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MedLine Citation:
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PMID: 22732362 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Lithium (Li) has been widely used as a long-term mood stabilizer in the treatment of bipolar and depressive disorders. Li(+) ions are thought to enhance the remyelination of peripheral nerves and also stimulate the proliferation of neural progenitor cells and retinoblastoma cells via activation of the Wnt/β-catenin signalling pathway. Until now there have been no studies reporting the biological effects of released Li(+) in bioactive scaffolds on cemetogenesis in periodontal tissue engineering applications. In this study, we incorporated parts of Li(+) ions into the mesoporous bioactive glass (MBG) scaffolds and showed that this approach yielded scaffolds with a favourable composition, microstructure and mesopore properties for cell attachment, proliferation, and cementogenic differentiation of human periodontal ligament-derived cells (hPDLCs). We went on to investigate the biological effects of Li(+) ions themselves on cell proliferation and cementogenic differentiation. The results showed that 5% Li(+) ions incorporated into MBG scaffolds enhanced the proliferation and cementogenic differentiation of hPDLCs on scaffolds, most likely via activation of Wnt/β-catenin signalling pathway. Further study demonstrated that Li(+) ions by themselves significantly enhanced the proliferation, differentiation and cementogenic gene expression of PDLCs. Our results indicate that incorporation of Li(+) ions into bioactive scaffolds is a viable means of enhancing the Wnt canonical signalling pathway to stimulate cementogenic differentiation of PDLCs. |
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Authors:
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Pingping Han; Chengtie Wu; Jiang Chang; Yin Xiao |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-23 |
Journal Detail:
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Title: Biomaterials Volume: - ISSN: 1878-5905 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Institute of Health & Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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