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The cellular and molecular mechanisms of immuno-suppression by human type 1 regulatory T cells.
MedLine Citation:
PMID:  22566914     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The immuno-regulatory mechanisms of IL-10-producing type 1 regulatory T (Tr1) cells have been widely studied over the years. However, several recent discoveries have shed new light on the cellular and molecular mechanisms that human Tr1 cells use to control immune responses and induce tolerance. In this review we outline the well known and newly discovered regulatory properties of human Tr1 cells and provide an in-depth comparison of the known suppressor mechanisms of Tr1 cells with FOXP3(+) T(reg). We also highlight the role that Tr1 cells play in promoting and maintaining tolerance in autoimmunity, allergy, and transplantation.
Authors:
Silvia Gregori; Kevin S Goudy; Maria Grazia Roncarolo
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Publication Detail:
Type:  Journal Article     Date:  2012-02-29
Journal Detail:
Title:  Frontiers in immunology     Volume:  3     ISSN:  1664-3224     ISO Abbreviation:  Front Immunol     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-08     Completed Date:  2012-08-23     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  101560960     Medline TA:  Front Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  30     Citation Subset:  -    
Affiliation:
Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), San Raffaele Scientific Institute Milan, Italy.
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