Document Detail


The cellular immunobiology associated with fetal and neonatal alloimmune thrombocytopenia.
MedLine Citation:
PMID:  21708486     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by maternal antibodies that cross the placenta in connection with pregnancy and destroy fetal platelets. Recently, maternal T cell responses associated with FNAIT have been studied at the clonal level. These T cell clones recognize an integrin β3 epitope, which is anchored to the HLA-DRB3∗0101-encoded MHC molecule DR52a. The same MHC allele is strongly associated with FNAIT. As the production of pathological antibodies reactive with fetal platelets is likely dependent on these T cell responses, there exists a potential for preventing FNAIT by targeting these T cells.
Authors:
Tor B Stuge; Bjørn Skogen; Maria Therese Ahlen; Anne Husebekk; Stanislaw J Urbaniak; Hagop Bessos
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-25
Journal Detail:
Title:  Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis     Volume:  -     ISSN:  1473-0502     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101095653     Medline TA:  Transfus Apher Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ltd.
Affiliation:
Laboratory Medicine, University Hospital of North Norway, Tromsø, Norway; Immunology Research Group, Institute of Medical Biology, University of Tromsø, Tromsø, Norway.
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