Document Detail

The cellular homeostasis of the gut: what the Drosophila model points out.
MedLine Citation:
PMID:  25293339     Owner:  NLM     Status:  Publisher    
The digestive tract is subjected to many aggressions throughout animal life. Since disruptions of gut physiology impact on animal fitness and survival, maintenance of gut integrity and functionality is essential for the individual. Over the last 40 years, research on rodents has aimed at understanding how cellular homeostasis of the digestive tract is maintained when challenged with disruptions. Following the discovery of stem cells in the digestive tract of Drosophila, a flurry of studies made an important contribution to our understanding of how the proliferation and the differentiation of these cells are controlled and participate in the renewal of the digestive tract. Insights into these mechanisms in Drosophila have revealed many similarities with mammalian intestinal stem cells. For instance, the highly conserved EGFR, JAK/STAT, Wingless/Wnt, Hedgehog, Integrins, BMP/TGFβ, Hippo and Insulin pathways all participate in adult intestinal cellular homeostasis. Here, we provide a literature review of recent advances in the field highlighting the adult Drosophila midgut as a convenient model for dissecting mechanisms involved in the maintenance of the cellular homeostasis of the digestive tract in conventionally reared conditions. In addition, we shed light on recently published data putting Drosophila forward as a genetic tool to decipher the mechanisms underlying intestinal diseases and intestinal tumour progression.
Matthieu Y Pasco; Rihab Loudhaief; Armel Gallet
Related Documents :
2537409 - Cholinergic stimulation of phosphoinositide hydrolysis in renal medullary collecting du...
2434139 - Inhibition of lymphoid cell growth by adenine ribonucleotide accumulation. the role of ...
11040039 - Cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine monophosphate: efficient intracel...
212849 - Estrogen synthetase in choriocarcinoma cell culture. stimulation by dibutyryl cyclic ad...
21734449 - Continuous hypoxia attenuates paraquat-induced cytotoxicity in the human a549 lung carc...
9587839 - Bovine trabecular cells produce timp-1 and mmp-2 in response to mechanical stretching.
10799689 - Modulation of g-protein linked camp accumulation in immortalized murine cortical astroc...
25114719 - Spindle cell carcinoma of the tongue: a rare variant of squamous cell carcinoma.
23119479 - Giant cell reparative granuloma of maxilla.
Publication Detail:
Type:  REVIEW     Date:  2014-10-8
Journal Detail:
Title:  Histology and histopathology     Volume:  -     ISSN:  1699-5848     ISO Abbreviation:  Histol. Histopathol.     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-9     Completed Date:  -     Revised Date:  2014-10-9    
Medline Journal Info:
Nlm Unique ID:  8609357     Medline TA:  Histol Histopathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Evaluation of social and nonsocial behaviors mediated by opioids in mouse pups.
Next Document:  Childhood obesity and insulin resistance: how should it be managed?