Document Detail


The cellular geometry of growth drives the amino acid economy of Caenorhabditis elegans.
MedLine Citation:
PMID:  19439436     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The nematode Caenorhabditis elegans grows largely by increases in cell size. As a consequence of this, the surface: volume ratio of its cells must decline in the course of postembryonic growth. Here we use transcriptomic and metabolomic data to show that this change in geometry can explain a variety of phenomena during growth, including: (i) changes in the relative expression levels of cytoplasmic and membrane proteins; (ii) changes in the relative usage of the twenty amino acids in expressed proteins, as estimated by changes in the transcriptome; and (iii) changes in metabolite pools of free amino acids. We expect these relations to be universal in single cells and in whole multicellular organisms that grow largely by increases in cell size, but not those that grow by cell proliferation.
Authors:
Jonathan Swire; Silke Fuchs; Jacob G Bundy; Armand M Leroi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-05-13
Journal Detail:
Title:  Proceedings. Biological sciences / The Royal Society     Volume:  276     ISSN:  0962-8452     ISO Abbreviation:  Proc. Biol. Sci.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-06-29     Completed Date:  2009-08-25     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  101245157     Medline TA:  Proc Biol Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2747-54     Citation Subset:  IM    
Affiliation:
Division of Molecular Biosciences, Imperial College London, London SW7 2AZ, UK.
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MeSH Terms
Descriptor/Qualifier:
Aging
Amino Acids / metabolism*
Animals
Caenorhabditis elegans / cytology,  growth & development*,  metabolism*
Cell Enlargement*
Cell Proliferation
Chemical
Reg. No./Substance:
0/Amino Acids
Comments/Corrections

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