Document Detail


The cellular biology of tendon grafting.
MedLine Citation:
PMID:  23303837     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We investigated the cellular biology of tendon grafting in a mouse model using green fluorescent protein mismatch grafting and quantitative immunohistochemistry of molecular markers for inflammation, proliferation, collagen synthesis, cell death, and myofibroblast/pericyte expression. We provide a detailed analysis of the healing characteristics during the phases of inflammation, synthesis, and remodelling. Our findings indicated that survival of the cells in the grafted tendon was finite. Syngenic and autologous grafts provoked a similar cellular reaction and all grafts healed. Cells in the graft contributed significantly to collagen synthesis and do have a role in healing.
Authors:
N Alam; D A McGrouther; J K F Wong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-8
Journal Detail:
Title:  The Journal of hand surgery, European volume     Volume:  -     ISSN:  2043-6289     ISO Abbreviation:  J Hand Surg Eur Vol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101315820     Medline TA:  J Hand Surg Eur Vol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Plastic Surgery Research, Inflammation Sciences, School of Translational Medicine, University of Manchester, Manchester, UK.
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