| The cellular basis for diverse responses to oxygen. | |
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MedLine Citation:
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PMID: 17189822 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mammalian cells have divergent responses to varying oxygen levels. Cells exposed to low oxygen levels (hypoxia) activate the transcription factor hypoxia-inducible factor-1 (HIF-1) as an adaptive response. Cells exposed to hypoxia do not undergo senescence or cell death and do not diminish ATP levels. By contrast, cells exposed to high oxygen levels (hyperoxia) undergo senescence and cell death and decrease their ATP levels, yet do not activate HIF-1. Despite these divergent responses with respect to senescence, cell death, metabolism, and gene expression, the signaling events in both systems are mediated by the generation of mitochondrial-derived reactive oxygen species (ROS). This perspective reviews the role of signaling through mitochondrial ROS in hypoxic and hyperoxic environments. |
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Authors:
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Navdeep S Chandel; G R Scott Budinger |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2006-10-28 |
Journal Detail:
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Title: Free radical biology & medicine Volume: 42 ISSN: 0891-5849 ISO Abbreviation: Free Radic. Biol. Med. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-12-26 Completed Date: 2007-02-22 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 8709159 Medline TA: Free Radic Biol Med Country: United States |
Other Details:
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Languages: eng Pagination: 165-74 Citation Subset: IM |
Affiliation:
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Department of Medicine and Department of Cell & Molecular Biology, Northwestern University, McGaw Pavilion M-334, 240 East Huron Avenue, Chicago, IL 60611, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / physiology Cell Aging / physiology Cell Hypoxia / physiology Humans Hypoxia-Inducible Factor 1 / metabolism Mitochondria / metabolism* Oxygen / metabolism* Reactive Oxygen Species / metabolism Signal Transduction / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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AG027093/AG/NIA NIH HHS; ES013995/ES/NIEHS NIH HHS; GM060472/GM/NIGMS NIH HHS; HL071643/HL/NHLBI NIH HHS; HL09315/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hypoxia-Inducible Factor 1; 0/Reactive Oxygen Species; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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