Document Detail

The cellular basis for allergic rhinitis.
MedLine Citation:
PMID:  7604953     Owner:  NLM     Status:  MEDLINE    
In both seasonal and perennial rhinitis there is epithelial mast cell accumulation and tissue infiltration by eosinophils. Activation of these cells can be observed by electron microscopy and by elevated levels of tryptase and eosinophil cationic protein in nasal lavage fluid. Furthermore, seasonal increases in the antigen presenting cell (Langerhans' cell) are also evident. Investigations into the mechanisms involved in cell accumulation and activation reveals upregulation of leucocyte endothelial adhesion molecules and an increase in interleukin-4 (IL-4) in naturally occurring rhinitis, while mRNA for IL-4, IL-5 and granulocyte macrophage colony stimulating factor activity and lavage tumour necrosis factor-alpha (TNF alpha) levels are increased following local allergen challenge. These cytokines may be derived from a variety of sources, including mast cells, eosinophils and T-lymphocytes, and contribute to the underlying inflammatory process in rhinitis.
P H Howarth
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Allergy     Volume:  50     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  1995  
Date Detail:
Created Date:  1995-08-07     Completed Date:  1995-08-07     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  6-10     Citation Subset:  IM    
Southampton General Hospital, UK.
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MeSH Terms
Basophils / pathology
Eosinophils / pathology
Inflammation / pathology
Mast Cells / pathology
Rhinitis, Allergic, Perennial / immunology,  pathology*
Rhinitis, Allergic, Seasonal / immunology,  pathology*
T-Lymphocytes / immunology

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