| The cellular basis for allergic rhinitis. | |
| | |
MedLine Citation:
|
PMID: 7604953 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In both seasonal and perennial rhinitis there is epithelial mast cell accumulation and tissue infiltration by eosinophils. Activation of these cells can be observed by electron microscopy and by elevated levels of tryptase and eosinophil cationic protein in nasal lavage fluid. Furthermore, seasonal increases in the antigen presenting cell (Langerhans' cell) are also evident. Investigations into the mechanisms involved in cell accumulation and activation reveals upregulation of leucocyte endothelial adhesion molecules and an increase in interleukin-4 (IL-4) in naturally occurring rhinitis, while mRNA for IL-4, IL-5 and granulocyte macrophage colony stimulating factor activity and lavage tumour necrosis factor-alpha (TNF alpha) levels are increased following local allergen challenge. These cytokines may be derived from a variety of sources, including mast cells, eosinophils and T-lymphocytes, and contribute to the underlying inflammatory process in rhinitis. |
| | |
Authors:
|
P H Howarth |
Related Documents
:
|
17362253 - Hepatocyte growth factor attenuates eotaxin and pgd2-induced chemotaxis of human eosino... 9371673 - The cytokine and histological response in islet xenograft rejection is dependent upon s... 21178273 - The essential role of dock8 in humoral immunity. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Allergy Volume: 50 ISSN: 0105-4538 ISO Abbreviation: Allergy Publication Date: 1995 |
Date Detail:
|
Created Date: 1995-08-07 Completed Date: 1995-08-07 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7804028 Medline TA: Allergy Country: DENMARK |
Other Details:
|
Languages: eng Pagination: 6-10 Citation Subset: IM |
Affiliation:
|
Southampton General Hospital, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Basophils
/
pathology Eosinophils / pathology Humans Inflammation / pathology Mast Cells / pathology Rhinitis, Allergic, Perennial / immunology, pathology* Rhinitis, Allergic, Seasonal / immunology, pathology* T-Lymphocytes / immunology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Treatment of seasonal allergic rhinitis with fluticasone propionate aqueous nasal spray: review of c...
Next Document: Direct determination of lithium in erythrocytes by electrothermal atomic absorption spectrometry.