| The cellular basis of GABA(B)-mediated interhemispheric inhibition. | |
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MedLine Citation:
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PMID: 22363012 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Interhemispheric inhibition is thought to mediate cortical rivalry between the two hemispheres through callosal input. The long-lasting form of this inhibition is believed to operate via γ-aminobutyric acid type B (GABA(B)) receptors, but the process is poorly understood at the cellular level. We found that the firing of layer 5 pyramidal neurons in rat somatosensory cortex due to contralateral sensory stimulation was inhibited for hundreds of milliseconds when paired with ipsilateral stimulation. The inhibition acted directly on apical dendrites via layer 1 interneurons but was silent in the absence of pyramidal cell firing, relying on metabotropic inhibition of active dendritic currents recruited during neuronal activity. The results not only reveal the microcircuitry underlying interhemispheric inhibition but also demonstrate the importance of active dendritic properties for cortical output. |
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Authors:
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Lucy M Palmer; Jan M Schulz; Sean C Murphy; Debora Ledergerber; Masanori Murayama; Matthew E Larkum |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 335 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 989-93 Citation Subset: IM |
Affiliation:
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Physiologisches Institut, Universität Bern, Bühlplatz 5, CH-3012 Bern, Switzerland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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