Document Detail

A cell spreading factor, abundant in human placenta, contains fibronectin and fibrinogen.
MedLine Citation:
PMID:  6190826     Owner:  NLM     Status:  MEDLINE    
A salt extract from human normal-term placental extracellular matrix contains material that rapidly adsorbs to glass or tissue-culture plastic and promotes the spreading of fibroblastic and epithelioid cell lines. The cellular response to placental spreading factor (PSF) is characterized and compared with the response to fibronectin. The active component is shown to contain antigenic determinants that cross-react with antibodies to fibronectin and fibrinogen. The activity is not retained on gelatin-Sepharose but another component of the extract (approximately 185 000 molecular weight) is retained. Partial purification is reported, and the possible involvement of PSF in trophoblastic invasion of the uterine wall is discussed.
J D Aplin; L J Foden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cell science     Volume:  58     ISSN:  0021-9533     ISO Abbreviation:  J. Cell. Sci.     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-08-11     Completed Date:  1983-08-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0052457     Medline TA:  J Cell Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  287-302     Citation Subset:  IM    
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MeSH Terms
Cell Adhesion / drug effects
Cell Movement
Electrophoresis, Polyacrylamide Gel
Epithelial Cells
Extracellular Space / analysis
Fibrinogen / analysis*
Fibroblasts / cytology
Fibronectins / analysis*
Glycoproteins / analysis
Hela Cells / cytology
Placenta / analysis*
Reg. No./Substance:
0/Fibronectins; 0/Glycoproteins; 0/Vitronectin; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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