Document Detail

The cell proliferation kinetics of psoriasis examined by three in vivo techniques.
MedLine Citation:
PMID:  1268049     Owner:  NLM     Status:  MEDLINE    
The cell proliferation kinetics of the germinative compartment in psoriasis have been re-investigated with tritiated thymidine and vincristine techniques. The mean cell cycle durations calculated from an extended fraction of labelled mitoses experiment were Tc=56 h, t1=43 h, ts=7-7 h and t2=5-6 h. Combination of the results of the FLM experiment with the experimental labelling index and the experimental birth rate suggests a growth fraction of unity and an exponential age distribution for the germinative population. An exponential age distribution is supported by the presence of several layers of germinative cells and the direction of the mitotic axes during cell division.
M Duffill; N Wright; S Shuster
Related Documents :
7127139 - Increased proliferation of oligodendrocytes in the hypomyelinated mouse mutant-jimpy.
9488499 - Acute acid exposure increases rabbit esophageal cell proliferation.
9879469 - Usefulness of pkhs for studying cell proliferation.
824809 - Cell kinetics of mouse urinary bladder epithelium. ii. changes in proliferation and nuc...
11292529 - Thymidine utilization abnormality in proliferating lymphocytes and hepatocytes of the w...
1431849 - Hormone accumulation in song regions of the canary brain.
15522499 - Anticancerogenic effect of a novel chiroinositol-containing polysaccharide from bifidob...
6598039 - Alveolar type i and type ii cells.
3012799 - Immunological studies with different classes of mutants affected at the adenosine kinas...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  94     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1976 Apr 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  355-62     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Middle Aged
Mitosis* / drug effects
Psoriasis / drug therapy,  pathology*
Skin / pathology
Vincristine / pharmacology,  therapeutic use
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Veno-occlusive lesions in the liver of rats after prolonged feeding with palmyrah (Borassus flabelli...
Next Document:  Simplification of local therapy of psoriasis with 8-methoxypsoralen. Methods and initial results.