Document Detail


The cell proliferation kinetics of psoriasis examined by three in vivo techniques.
MedLine Citation:
PMID:  1268049     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cell proliferation kinetics of the germinative compartment in psoriasis have been re-investigated with tritiated thymidine and vincristine techniques. The mean cell cycle durations calculated from an extended fraction of labelled mitoses experiment were Tc=56 h, t1=43 h, ts=7-7 h and t2=5-6 h. Combination of the results of the FLM experiment with the experimental labelling index and the experimental birth rate suggests a growth fraction of unity and an exponential age distribution for the germinative population. An exponential age distribution is supported by the presence of several layers of germinative cells and the direction of the mitotic axes during cell division.
Authors:
M Duffill; N Wright; S Shuster
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  94     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1976 Apr 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  355-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Female
Humans
Kinetics
Male
Middle Aged
Mitosis* / drug effects
Psoriasis / drug therapy,  pathology*
Skin / pathology
Vincristine / pharmacology,  therapeutic use
Chemical
Reg. No./Substance:
57-22-7/Vincristine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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