Document Detail

The cell-growth inhibitory effect of interferon. Studies of a resistant cell-subline.
MedLine Citation:
PMID:  194167     Owner:  NLM     Status:  MEDLINE    
Studies performed in the CSV subline of mouse L-cells suggest that activated endogenous and/or exogenous viral infection might be the factor that modifies the cell surface and, in consequence, the sensitivity of the cell to the cell-growth inhibitory action of interferon. In contrast with the parental L-cells, the CSV subline obtained by prolonged passage of L-cells in the presence of interferon shows an altered electron microscopic morphology, absence of C type particles and a decreased agglutinability with Concanavalin A. It is resistant to the cell-growth inhibitory effect of interferon but retains the sensitivity toward its antiviral effect. However, the sensitivity of the CSV subline toward the cell-growth inhibitory effect of interferon increased significantly after treatment with 5-iododexyuridine, infection with the Harvey strain of mouse sarcoma virus and/or prolonged passages in vitro. In this respect, the CSV subline resembles the primary mouse embryonic cells. Since sensitivity of CSV cells increased also after treatment with cyclic 3'-5' adenosine monophosphate and/or prostaglandin E2, it is possible that the cell-growth inhibitory effect of interferon is mediated through the "second messenger" system.
L Borecký; N Fuchsberger; V Hajnická-Gondová; F Clampor; C Altaner
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Neoplasma     Volume:  24     ISSN:  0028-2685     ISO Abbreviation:  Neoplasma     Publication Date:  1977  
Date Detail:
Created Date:  1977-07-29     Completed Date:  1977-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0377266     Medline TA:  Neoplasma     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  125-37     Citation Subset:  IM    
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MeSH Terms
Cell Division / drug effects
Cyclic AMP / pharmacology
Idoxuridine / pharmacology
Interferons / pharmacology*
L Cells (Cell Line) / drug effects*,  ultrastructure
Oncogenic Viruses
Prostaglandins E / pharmacology
Reg. No./Substance:
0/Prostaglandins E; 54-42-2/Idoxuridine; 60-92-4/Cyclic AMP; 9008-11-1/Interferons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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