Document Detail

The cell cycle time in the flat (avillous) mucosa of the human small intestine.
MedLine Citation:
PMID:  4270325     Owner:  NLM     Status:  MEDLINE    
A hyperproductive mucosal state in gluten-sensitive enteropathy has been proposed on the basis of an elevated mitotic index, but this parameter is dependent on the mitotic duration when used as an index of proliferative status. The mitotic duration was therefore measured in two control patients with normal villous mucosae and in two patients with the flat avillous mucosa of untreated gluten-sensitive enteropathy, using two different stathmokinetic techniques with vincristine. No significant difference in mitotic duration was found but values obtained for cell cycle time showed a halving in the flat mucosae. An increased rate of cell production in the small bowel mucosa of untreated gluten-sensitive enteropathy is thus confirmed.
N Wright; A Watson; A Morley; D Appleton; J Marks; A Douglas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  14     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1973 Aug 
Date Detail:
Created Date:  1973-12-13     Completed Date:  1973-12-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  603-6     Citation Subset:  AIM; IM    
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MeSH Terms
Anemia, Macrocytic / pathology
Celiac Disease / pathology
Diarrhea / pathology
Folic Acid Deficiency / pathology
Intestinal Mucosa / cytology*
Intestine, Small / cytology*
Leg Ulcer / pathology
Middle Aged
Rosacea / pathology
Time Factors
Vincristine / pharmacology
Reg. No./Substance:
57-22-7/Vincristine; 8002-80-0/Glutens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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