| The cell cycle molecules behind neurodegeneration in Alzheimer's disease: perspectives for drug development. | |
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MedLine Citation:
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PMID: 18855671 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alzheimer's disease (AD), the leading cause of senile dementia, has become a considerable social and economical problem. Current AD therapeutics provide mainly symptomatic short-term benefit, rather than targeting disease mechanisms. The hallmarks for AD are beta-amyloid plaques, neurofibrillary tangles, and regionalized neuronal loss. Additional neuropathological features have been described that may provide some clues to the mechanism by which neurons die in AD. Specifically, the aberrant expression of cell cycle proteins and the presence of de novo-replicated DNA in neurons have been described both in AD brain and in culture models of the disease. The unscheduled cell cycle events are deleterious to neurons, which undergo death rather than complete the cell cycle. Although our understanding of the neuronal cell cycle is not complete, experimental evidence suggests that compounds able of arresting the aberrant cell cycle will yield neuroprotection. This review focuses on drug development centered on the cell cycle hypothesis of AD. |
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Authors:
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A Copani; S Guccione; L Giurato; F Caraci; M Calafiore; M A Sortino; F Nicoletti |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current medicinal chemistry Volume: 15 ISSN: 0929-8673 ISO Abbreviation: Curr. Med. Chem. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-10-15 Completed Date: 2008-10-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9440157 Medline TA: Curr Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 2420-32 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences, CNR-Catania, Catania, Italy. acopani@katamail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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drug therapy*,
metabolism,
pathology* Animals Cell Cycle / drug effects* Drug Evaluation, Preclinical Humans Models, Neurological Nerve Degeneration / drug therapy*, metabolism*, pathology Neuroprotective Agents / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Neuroprotective Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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