Document Detail

The cell cycle and human neurodegenerative disease.
MedLine Citation:
PMID:  14593698     Owner:  NLM     Status:  MEDLINE    
The mechanism by which neurons die in human neurodegenerative diseases remains an enigma till today. Terminally differentiated neurons of normal brain are incapable of cell division. However, accumulating evidence has suggested that aberrant activation of the cell cycle in certain degenerative diseases leads to their demise. In Alzheimer's disease, regulators spanning every phase of the cell cycle are upregulated in affected neurons, leading to successful DNA replication, but unsuccessful mitosis. The end point of this nonproductive cycle of division is death. Elucidating the details of this cell cycle-mediated degenerative cascade may lead to novel strategies for curbing the onset and progression of degenerative diseases.
Inez Vincent; Chong In Pae; Janice L Hallows
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Progress in cell cycle research     Volume:  5     ISSN:  1087-2957     ISO Abbreviation:  Prog Cell Cycle Res     Publication Date:  2003  
Date Detail:
Created Date:  2003-11-03     Completed Date:  2003-12-11     Revised Date:  2008-11-17    
Medline Journal Info:
Nlm Unique ID:  9609058     Medline TA:  Prog Cell Cycle Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  31-41     Citation Subset:  IM    
Department of Pathology, University of Washington, Box 357705, Seattle, WA 98195, USA.
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MeSH Terms
Cell Cycle / genetics*
Cell Cycle Proteins / genetics
Cell Death / genetics*
Genes, cdc / physiology
Nerve Tissue Proteins / genetics,  metabolism
Neurodegenerative Diseases / genetics*,  metabolism,  therapy
Neurons / metabolism*,  pathology
Grant Support
Reg. No./Substance:
0/Cell Cycle Proteins; 0/Nerve Tissue Proteins

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