| The cell cycle of early mammalian embryos: lessons from genetic mouse models. | |
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MedLine Citation:
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PMID: 16481745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Genes coding for cell cycle components predicted to be essential for its regulation have been shown to be dispensable in mice, at the whole organism level. Such studies have highlighted the extraordinary plasticity of the embryonic cell cycle and suggest that many aspects of in vivo cell cycle regulation remain to be discovered. Here, we discuss the particularities of the mouse early embryonic cell cycle and review the mutations that result in cell cycle defects during mouse early embryogenesis, including deficiencies for genes of the cyclin family (cyclin A2 and B1), genes involved in cell cycle checkpoints (Mad2, Bub3, Chk1, Atr), genes involved in ubiquitin and ubiquitin-like pathways (Uba3, Ubc9, Cul1, Cul3, Apc2, Apc10, Csn2) as well as genes the function of which had not been previously ascribed to cell cycle regulation (Cdc2P1, E4F and Omcg1). |
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Authors:
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Jérôme Artus; Charles Babinet; Michel Cohen-Tannoudji |
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Publication Detail:
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Type: Journal Article; Review Date: 2006-03-01 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 5 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-27 Completed Date: 2006-05-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 499-502 Citation Subset: IM |
Affiliation:
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Unité de Biologie du Développement, CNRS URA 2578, Institut Pasteur, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / genetics*, physiology* Embryo, Mammalian / cytology*, metabolism* Embryonic Development Gene Targeting Mice Models, Genetic* Ubiquitin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Ubiquitin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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