| The cell cycle during amphibian limb regeneration. | |
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MedLine Citation:
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PMID: 1270529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The duration of the cell cycle in the blastema of regenerating limbs of axolotls has been measured by means of [3H]thymidine pulse labelling and autoradiography. A chase was required to define the pulse period. An average cell cycle at 20 degrees C takes 53 h, S-phase takes 38 h; including parts of mitosis, G1 is 10 h and G2 is 5 h long. The protracted cycle and S-phase are consonant with the large genome in axolotis and other urodeles. The rapidly growing blastema probably contains a steady population of about 5000 proliferating cells, as there is a regular withdrawal of differentiating cells from the population. The kinds of determination which exist in this population of cells, or are exerted on it, are briefly considered. |
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Authors:
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H Wallace; M Maden |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cell science Volume: 20 ISSN: 0021-9533 ISO Abbreviation: J. Cell. Sci. Publication Date: 1976 May |
Date Detail:
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Created Date: 1976-08-02 Completed Date: 1976-08-02 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0052457 Medline TA: J Cell Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 539-47 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ambystoma
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physiology* Animals Autoradiography Cell Division* Cell Nucleus / metabolism Extremities / physiology* Mitosis Regeneration* Thymidine / metabolism |
| Chemical | |
Reg. No./Substance:
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50-89-5/Thymidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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