| The cell cycle: a critical therapeutic target to prevent vascular proliferative disease. | |
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MedLine Citation:
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PMID: 16498512 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Percutaneous coronary intervention is the preferred revascularization approach for most patients with coronary artery disease. However, this strategy is limited by renarrowing of the vessel by neointimal hyperplasia within the stent lumen (in-stent restenosis). Vascular smooth muscle cell proliferation is a major component in this healing process. This process is mediated by multiple cytokines and growth factors, which share a common pathway in inducing cell proliferation: the cell cycle. The cell cycle is highly regulated by numerous mechanisms ensuring orderly and coordinated cell division. The present review discusses current concepts related to regulation of the cell cycle and new therapeutic options that target aspects of the cell cycle. |
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Authors:
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Thierry Charron; Nafiseh Nili; Bradley H Strauss |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Canadian journal of cardiology Volume: 22 Suppl B ISSN: 1916-7075 ISO Abbreviation: Can J Cardiol Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-02-24 Completed Date: 2007-09-20 Revised Date: 2010-09-15 |
Medline Journal Info:
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Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: Canada |
Other Details:
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Languages: eng Pagination: 41B-55B Citation Subset: IM |
Affiliation:
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Roy and Ann Foss International Cardiology Research Program, Terrence Donnelly Heart Centre, St Micheal's Hospital, University of Toronto, Ontario. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary Animals Cell Cycle* / drug effects Cell Proliferation / drug effects* Coronary Artery Disease / physiopathology, therapy Coronary Restenosis / pathology, physiopathology*, prevention & control* Gene Therapy Humans Hyperplasia Muscle, Smooth, Vascular / cytology* Tunica Intima / pathology |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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