Document Detail

A G2/M cell cycle block in transformed cells by contact with normal neighbors.
MedLine Citation:
PMID:  12963849     Owner:  NLM     Status:  MEDLINE    
Neighbour suppression of growth of tumour cells by stationary normal cells might be important in early stages of cancer. We have studied this using suppressor and non-suppressor lines of 3T3 fibroblasts and SV40 transformed derivatives. Growth suppression of transformed cells depended on direct contact with stationary confluent cultures of 3T3 cells but not on gap junction communication. It was not caused by apoptosis nor through the normal G0/G1 block present in the confluent normal cells. Instead, there was a progressive elongation of the cell cycle leading to arrest in G2/M in the transformed cells. This indicates an unusual type of growth arrest not previously involved in social control of cell growth.
David Allard; Michael Stoker; Ermanno Gherardi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  2     ISSN:  1538-4101     ISO Abbreviation:  Cell Cycle     Publication Date:    2003 Sep-Oct
Date Detail:
Created Date:  2003-09-09     Completed Date:  2004-05-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  484-7     Citation Subset:  IM    
Medical Research Council Centre, Laboratory of Molecular Biology, Cambridge, UK.
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MeSH Terms
Antigens, Polyomavirus Transforming / metabolism
Cell Adhesion / physiology*
Cell Communication / physiology*
Cell Cycle / physiology*
Cell Transformation, Neoplastic / metabolism*
Extracellular Matrix / metabolism*
Swiss 3T3 Cells
Tumor Cells, Cultured
Reg. No./Substance:
0/Antigens, Polyomavirus Transforming
Comment In:
Cell Cycle. 2003 Sep-Oct;2(5):454   [PMID:  12963842 ]

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