| Eosinophilic/T-cell chorionic vasculitis. | |
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MedLine Citation:
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PMID: 12016525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chorionic vasculitis is the hallmark of a fetal response in chorioamnionitis. There are five highly characteristic findings: (1) leukocyte migration is not concentric but rather radiates toward the infected amniotic fluid; (2) the infiltrate is primarily neutrophils; (3) multiple chorionic vessels, first veins and then arteries, are usually involved; (4) the infiltrate never extends into the vasculature of stem villi; and (5) it is rare in the absence of chorioamnionitis (or its precursors). Here we describe a new form of chorionic vasculitis characterized by an infiltrate composed primarily of eosinophils and CD3+ T lymphocytes that very focally involves a single chorionic vessel (artery or vein), that radiates away from the amniotic fluid (i.e., toward the intervillous spaces), and that may extend into the stem villous vasculature; this lesion occurs in the absence of any evidence of chorioamnionitis. During the past 7+ years, using accepted placental review criteria, we have examined 7104 placentas and identified 14 cases of eosinophilic/T-cell chorionic vasculitis (or related lesions). Although the frequency of diagnosis in the placentas examined was 0.197%, its true incidence cannot be estimated because of its very focal nature and the limited nature of placental disk sampling. Its etiology and significance are unknown, but it may represent a focal immune-mediated vasculitis. |
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Authors:
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Robert B Fraser; James R Wright |
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Publication Detail:
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Type: Journal Article Date: 2002-05-21 |
Journal Detail:
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Title: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Volume: 5 ISSN: 1093-5266 ISO Abbreviation: Pediatr. Dev. Pathol. Publication Date: 2002 Jul-Aug |
Date Detail:
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Created Date: 2002-08-28 Completed Date: 2003-02-07 Revised Date: 2006-05-08 |
Medline Journal Info:
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Nlm Unique ID: 9809673 Medline TA: Pediatr Dev Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 350-5 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, IWK Health Centre and Dalhousie University, 5850 University Avenue, Halifax, Nova Scotia B3H 1V7, Canada. robert.fraser@iwk.nshealth.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD Chorion / metabolism, pathology* Eosinophilia / metabolism, pathology Eosinophils / metabolism, pathology* Female Humans Placenta Diseases / metabolism, pathology Pregnancy Pregnancy Complications / metabolism, pathology T-Lymphocytes / metabolism, pathology* Vasculitis / metabolism, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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