| The cell boundary theorem: a simple law of the control of cytosolic calcium concentration. | |
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MedLine Citation:
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PMID: 19937486 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many molecular biological interventions in current use, as well as inheritable disease conditions, modify the intracellular endowment of molecules that bind Ca(2+) or channels and pumps that transfer it to and from intracellular storage organelles. A simple law, named the "cell boundary theorem," states that intracellular alterations cannot directly result in changes in the cytosolic concentration, [Ca(2+)](i), in a true resting state. A demonstration of the validity of this theorem is provided. Several examples are then discussed of interventions or diseases that increase leak of Ca(2+) from storage organelles and result in greater resting [Ca(2+)](i). According to the theorem, the increase in [Ca(2+)](i) cannot be a direct consequence of the greater leak. Its primary cause must be a change of the fluxes at the level of the plasmalemma, caused in turn by the increase in leak through some sort of "store-operated Ca(2+) entry." While the law is discussed in terms of Ca(2+) homeostasis, it applies to any solute that may be transported by the plasma membrane. |
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Authors:
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Eduardo Ríos |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-11-26 |
Journal Detail:
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Title: The journal of physiological sciences : JPS Volume: 60 ISSN: 1880-6562 ISO Abbreviation: J Physiol Sci Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-04-02 Revised Date: 2013-04-03 |
Medline Journal Info:
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Nlm Unique ID: 101262417 Medline TA: J Physiol Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 81-4 Citation Subset: IM |
Affiliation:
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Section of Cellular Signaling, Department of Molecular Biophysics and Physiology, Rush University, 1750 Chicago, IL 60612, USA. erios@rush.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism* Cell Membrane / metabolism* Cytosol / metabolism* Homeostasis* Models, Biological |
| Grant Support | |
ID/Acronym/Agency:
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AR032808/AR/NIAMS NIH HHS; AR0490184/AR/NIAMS NIH HHS; R01 AR032808-26/AR/NIAMS NIH HHS; R01 AR049184/AR/NIAMS NIH HHS; R01 AR049184-06A1/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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7440-70-2/Calcium |
| Comments/Corrections | |
Comment In:
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J Physiol Sci. 2013 Mar;63(2):159
[PMID:
23263921
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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