Document Detail

The cell biology of cell-in-cell structures.
MedLine Citation:
PMID:  18784728     Owner:  NLM     Status:  MEDLINE    
For decades, authors have described unusual cell structures, referred to as cell-in-cell structures, in which whole cells are found in the cytoplasm of other cells. One well-characterized process that results in the transient appearance of such structures is the engulfment of apoptotic cells by phagocytosis. However, many other types of cell-in-cell structure have been described that involve viable non-apoptotic cells. Some of these structures seem to form by the invasion of one cell into another, rather than by engulfment. The mechanisms of cell-in-cell formation and the possible physiological roles of these processes will be discussed.
Michael Overholtzer; Joan S Brugge
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-09-11
Journal Detail:
Title:  Nature reviews. Molecular cell biology     Volume:  9     ISSN:  1471-0080     ISO Abbreviation:  Nat. Rev. Mol. Cell Biol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-24     Completed Date:  2008-10-06     Revised Date:  2009-12-02    
Medline Journal Info:
Nlm Unique ID:  100962782     Medline TA:  Nat Rev Mol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  796-809     Citation Subset:  IM    
Cell Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA.
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MeSH Terms
Apoptosis / physiology
Cell Communication
Cell Fusion
Cellular Structures / physiology*
Cytoplasmic Vesicles / physiology
Genomic Instability
Models, Biological
Neoplasms / pathology,  physiopathology
Phagocytosis / physiology*
Vacuoles / physiology

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