| The cell biology of blastocyst development. | |
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MedLine Citation:
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PMID: 1335276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Preimplantation development encompasses the "free"-living period of mammalian embryogenesis, which culminates in the formation of a fluid-filled structure, the blastocyst. Cavitation (blastocyst formation) is accompanied by the expression of a novel set of gene products that contribute directly to the attainment of cell polarity with the trophectoderm, which is both the first epithelium of development and the outer cell layer encircling the inner cell mass of the blastocyst. Several of these gene products have been identified and include the tight junction (ZO-1), Na/K-ATPase (alpha and beta subunits), uvomorulin, gap junction (connexin43), and growth factors such as transforming growth factor-alpha (TGF-alpha) and epidermal growth factor (EGF). This review will examine the role(s) of each of these gene products during the onset and progression of blastocyst formation. The trophectodermal tight junctional permeability seal regulates the leakage of blastocoel fluid and also assists in the maintenance of a polarized Na/K-ATPase distribution to the basolateral plasma membrane domain of the mural trophectoderm. The polarized distribution of the Na/K-ATPase plays an integral role in the establishment of a trans-trophectoderm Na+ gradient, which drives the osmotic accumulation of water across the epithelium into the nascent blastocoelic cavity. The cell adhesion provided by uvomorulin is necessary for the establishment of the tight junctional seal, as well as the maintenance of the polarized Na/K-ATPase distribution. Growth factors such as TGF-alpha and EGF stimulate an increase in the rate of blastocoel expansion, which could, in part, be mediated by secondary messengers that result in an increase in Na/K-ATPase activity. Insight into the mechanism of cavitation has, therefore, directly linked blastocyst formation to trophectoderm cell differentiation, which arises through fundamental cell biological processes that are directly involved in the attainment of epithelial cell polarity. |
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Authors:
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A J Watson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Molecular reproduction and development Volume: 33 ISSN: 1040-452X ISO Abbreviation: Mol. Reprod. Dev. Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-01-29 Completed Date: 1993-01-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8903333 Medline TA: Mol Reprod Dev Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 492-504 Citation Subset: IM |
Affiliation:
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Department of Medical Biochemistry, University of Calgary Health Sciences Center, Alberta, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blastocyst / cytology*, physiology Embryonic and Fetal Development / genetics, physiology* Female Gene Expression Growth Substances / physiology Humans Ion Transport Models, Biological Pregnancy Sodium-Potassium-Exchanging ATPase / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Growth Substances; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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