| Is cell aging caused by respiration-dependent injury to the mitochondrial genome? | |
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MedLine Citation:
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PMID: 7037547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Though intrinsic mitochondrial aging has been considered before as a possible cause of cellular senescence, the mechanisms of such mitochondrial aging have remained obscure. In this article we expand on our hypothesis of free-radical-induced inhibition of mitochondrial replenishment in fixed postmitotic cells. We maintain that the respiration-dependent production of superoxide and hydroxyl radicals may not be fully counteracted, leading to a continuous production of lipoperoxides and malonaldehyde in actively respiring mitochondria. These compounds, in turn, can easily react with the mitochondrial DNA which is in close spatial relationship with the inner mitochondrial membrane, producing an injury that the mitochondria may be unable to counteract because of their apparent lack of adequate repair mechanisms. Mitochondrial division may thus be inhibited leading to age-related reduction of mitochondrial numbers, a deficit in energy production with a concomitant decrease in protein synthesis, deterioration of physiological performance, and therefore, of organismic performance. |
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Authors:
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J E Fleming; J Miquel; S F Cottrell; L S Yengoyan; A C Economos |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Gerontology Volume: 28 ISSN: 0304-324X ISO Abbreviation: Gerontology Publication Date: 1982 |
Date Detail:
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Created Date: 1982-05-27 Completed Date: 1982-05-27 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7601655 Medline TA: Gerontology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 44-53 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Survival* DNA, Mitochondrial / physiology* Free Radicals Lipid Peroxides / physiology Malondialdehyde Oxygen Consumption* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Mitochondrial; 0/Free Radicals; 0/Lipid Peroxides; 542-78-9/Malondialdehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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