Document Detail


On-cell MAS NMR: physiological clues from living cells.
MedLine Citation:
PMID:  23030432     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
While structural information on biomolecules is mainly obtained from purified in-vitro samples, NMR can also be applied in the context of entire cells or organisms. The present study describes maturation processes in living Salmonella enterica, a prevalent cause for human gastroenteritis. In our physiological study we follow the composition of the O-antigen on the outer bacterial membrane with high-resolution MAS-NMR spectroscopy. We detect and characterize an evolution of the O-antigen composition, in particular of the O-acetylation state of the O-antigen, a factor that can play an important role in vaccine development.
Authors:
Giorgia Zandomeneghi; Karin Ilg; Markus Aebi; Beat H Meier
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-2
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  -     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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