| Eosinophilic/T-cell Chorionic Vasculitis: A Clinicopathologic and Immunohistochemical Study of 51 Cases. | |
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MedLine Citation:
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PMID: 21050080 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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ABSTRACT We report 51 placentas diagnosed with eosinophilic/T-cell chorionic vasculitis (E/TCV), an unusual form of chorionic vasculitis characterized by an infiltrate composed predominantly of CD3+ T cells and eosinophils. The placentas were all 3rd trimester, with 48 (94.1%) being term. Forty-seven (92.2%) were singleton placentas, and the remaining 4 were twins. The E/TCV was limited to 1 chorionic surface vessel in 40 (78.4%) and involved 50% or less of the vessel circumference in 30 (58.8%) placentas. The inflammation faced the intervillous space in 12 (23.5%) and the amniotic cavity in 8 (15.7%) and had no distinct predominant direction in the remaining 31 (60.8%) placentas. Twelve (25.5%) placentas showed mural thrombi or intramural fibrin in association with the E/TCV. One hundred six term singleton placentas were selected as the control group, and the 47 singleton placentas with E/TCV made up the study group for comparison of demographic and histopathologic features. Villitis of unknown etiology was identified more frequently in study group placentas (20 [42.6%]) compared with control group placentas (14 [13.2%]) (P < 0.001). Vascular changes of fetal vascular thrombo-occlusive disease were identified away from the E/TCV more frequently in study group placentas (8 [17.0%]) compared with control group placentas (4 [3.8%]) (P = 0.008). There were no significant differences in the frequencies of other placental lesions studied, including acute inflammatory lesions and lesions related to maternal underperfusion. There were no significant differences in maternal age, race, parity, birth weight, allergy history, blood type, or medication use. |
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Authors:
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Suzanne M Jacques; Faisal Qureshi; Chong Jai Kim; Joon Ho Lee; Tamar Giorgadze; Pooja Mittal; Sonia S Hassan; Roberto Romero |
Publication Detail:
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Type: Journal Article Date: 2010-11-04 |
Journal Detail:
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Title: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Volume: 14 ISSN: 1093-5266 ISO Abbreviation: Pediatr. Dev. Pathol. Publication Date: 2011 May-Jun |
Date Detail:
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Created Date: 2011-08-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9809673 Medline TA: Pediatr Dev Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 198-205 Citation Subset: IM |
Affiliation:
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1 Department of Pathology, Detroit Medical Center and Wayne State University School of Medicine, Hutzel Women's Hospital, 3990 John R. Street, Detroit, MI 48201, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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