Document Detail

The causes of low oestrogen excretion in pregnancy: assessment of the fetal contribution by steroid measurements post partum.
MedLine Citation:
PMID:  7437377     Owner:  NLM     Status:  MEDLINE    
Oestrogen levels in urine from 21 normotensive and 13 hypertensive pregnant women were moderately correlated (r = 0.48) with levels of 3 beta-hydroxy-5-ene steroids (oestrogen precursors) in urine from their infants. In five infants from otherwise normal pregnancies in which oestrogen excretion was very low, levels of 3 beta-hydroxy-5-ene steroids were significantly lower than normal while there was no difference between hypertensives and normals. Levels of urinary cortisol metabolites in the infants were moderately correlated with 3 beta-hydroxy-5-ene steroids (r = 0.55) and were especially low in 2 out of 5 infants in the series suffering from distress during delivery. We conclude that subnormal fetal steroidogenesis rather than reduced placental metabolism is the most common cause of low oestrogen excretion of unknown aetiology. A factor in the increased perinatal risk in this group may be an associated insufficient cortisol synthesis by the fetus.
N F Taylor; R S Philip; C H Shackleton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  87     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-02-26     Completed Date:  1981-02-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1087-94     Citation Subset:  AIM; IM    
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MeSH Terms
Birth Weight
Estrogens / urine*
Hydrocortisone / urine
Hypertension / urine
Infant, Newborn
Pregnancy Complications, Cardiovascular / urine
Steroids / urine
Reg. No./Substance:
0/Estrogens; 0/Steroids; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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