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Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through promoting the ROS production.
MedLine Citation:
PMID:  23124852     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Recent studies have demonstrated that the Wnt/β-catenin signaling plays an important role in stem cell aging. However, the mechanisms of cell senescence induced by Wnt/β-catenin signaling are still poorly understood. Our preliminary study has indicated that activated Wnt/β-catenin signaling can induce MSC aging. In this study, we reported that the Wnt/β-catenin signaling was a potent activator of reactive oxygen species (ROS) generation in MSCs. After scavenging ROS with N-acetylcysteine, Wnt/β-catenin signaling-induced MSC aging was significantly attenuated and the DNA damage and the expression of p16(INK4A), p53, and p21 were reduced in MSCs. These results indicated that the Wnt/β-catenin signaling could induce MSC aging through promoting the intracellular production of ROS, and ROS may be the main mediators of MSC aging induced by excessive activation of Wnt/β-catenin signaling.
Authors:
Da-Yong Zhang; Yu Pan; Chong Zhang; Bing-Xi Yan; Shan-Shan Yu; Dong-Ling Wu; Meng-Meng Shi; Kai Shi; Xin-Xiao Cai; Shuang-Shuang Zhou; Jun-Bo Wang; Jian-Ping Pan; Li-Huang Zhang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-3
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  -     ISSN:  1573-4919     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Basic Medicine, School of Medicine and Life Sciences, Zhejiang University City College, 51 Huzhou Street, Hangzhou, 310015, People's Republic of China.
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