| The catecholamine mechanisms of prostaglandin E1-induced hypothermia in rats. | |
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MedLine Citation:
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PMID: 6105185 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intraperitoneal administration of prostaglandin E1 (PGE1) produced a hypothermia in rats at room temperatue (22 degrees C). The hypothermia in response to PGE1 was due to cutaneous vasodilatation and decreased metabolic heat production. Depletion of brain 5-hydroxytryptamine (with 5,6-dihydroxytryptamine and p-chlorophenylalanine) did not alter the PGE1-induced hypothermia. However, depletion of bran catecholamines (with 6-hydroxydopamine) and blockade of central catecholaminergic receptors (with phentolamine and propranolol) both greatly reduced the PGE1-induced hypothermia. The data indicate that PGE1 lowers body temperature in rats by acting on the central catecholaminergic systems. |
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Authors:
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M T Lin; A Chandra; R Sun; C L Kau |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 32 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 1980 Jul |
Date Detail:
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Created Date: 1980-10-27 Completed Date: 1980-10-27 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 489-92 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature / drug effects Brain / drug effects* Brain Chemistry / drug effects Catecholamines / physiology* Hypothermia / chemically induced* Male Prostaglandins E / pharmacology* Rats Receptors, Adrenergic / drug effects Receptors, Serotonin / drug effects Serotonin / analysis |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Prostaglandins E; 0/Receptors, Adrenergic; 0/Receptors, Serotonin; 50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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