| Is caseinomacropeptide from milk proteins, an inhibitor of gastric secretion? | |
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MedLine Citation:
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PMID: 19761803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this work was to study, in vivo, the effect of the ingestion of not glycosylated caseinomacropeptide (CMP) on gastric secretion. In Experiments #1 and #2, 7 calves fitted with a gastric pouch received either a diet without CMP (C diet) or C diet in which CMP was introduced (equal to and 5 folds that of CMP quantity contained in cow milk, diets CMP1 and CMP5, respectively). In Experiment #3, 2 calves (with gastric pouch) were fed C diet followed by an "iv perfusion" of CMP. In Experiment #4, 25 calves fed either C, CMP1 or CMP5 diets were fitted with a blood catheter for sample collections. The quantities of daily gastric secretions seemed few modified by CMP ingestion but the profile of these secretions was changed along the day. The most important result is that CMP can inhibit gastric secretions (mainly hydrochloric acid) stimulated by the meal, but there was no dose-dependent response. No similar observations were obtained after perfusion of CMP in jugular vein. CMP was not detected in blood. Results obtained in our experiments are not in favor of its significant intestinal absorption. Gastrin, somatostatin and VIP could be implicated in the mechanisms of regulation. |
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Authors:
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Paul Guilloteau; V?ronique Rom?; Luc Delaby; Fran?ois Mendy; Loic Roger; Jean Alain Chayvialle |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Regulatory peptides Volume: 159 ISSN: 1873-1686 ISO Abbreviation: Regul. Pept. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-02-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100479 Medline TA: Regul Pept Country: Netherlands |
Other Details:
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Languages: eng Pagination: 129-36 Citation Subset: IM |
Affiliation:
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INRA, UMR SENAH, Domaine de la Prise, 35590 Saint Gilles, France. Paul.Guilloteau@rennes.inra.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caseins / pharmacology* Cattle Gastric Acid / secretion* Gastric Mucosa / secretion* Gastrins / metabolism Somatostatin / metabolism Vasoactive Intestinal Peptide / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Caseins; 0/Gastrins; 37221-79-7/Vasoactive Intestinal Peptide; 51110-01-1/Somatostatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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