| A case of withdrawal from the GHB precursors gamma-butyrolactone and 1,4-butanediol. | |
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MedLine Citation:
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PMID: 11399385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a case of withdrawal from the gamma hydroxybutyric acid (GHB) precursors gamma butyrolactone and 1,4-butanediol. Symptoms included visual hallucinations, tachycardia, tremor, nystagmus, and diaphoresis. Administration of benzodiazepines and phenobarbital successfully treated the withdrawal symptoms. As predicted from the metabolism of gamma butyrolactone and 1,4-butanediol to GHB, the symptoms were nearly identical to those reported from GHB withdrawal. Because GHB is now illegal in the United States, individuals have begun abusing the legal and easier to acquire GHB precursors. More frequent cases of both abuse and withdrawal from these GHB precursors can be expected. |
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Authors:
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A B Schneir; B T Ly; R F Clark |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of emergency medicine Volume: 21 ISSN: 0736-4679 ISO Abbreviation: J Emerg Med Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-06-11 Completed Date: 2001-07-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8412174 Medline TA: J Emerg Med Country: United States |
Other Details:
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Languages: eng Pagination: 31-3 Citation Subset: IM |
Affiliation:
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Division of Medical Toxicology, Department of Emergency Medicine, UCSD Medical Center, California Poison Control System-San Diego Division, 200 West Arbor Drive, San Diego, CA 92103-8925, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4-Butyrolactone
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adverse effects* Adult Anticonvulsants / therapeutic use Diazepam / therapeutic use Drug Therapy, Combination Emergencies Humans Lorazepam / therapeutic use Male Phenobarbital / therapeutic use Substance Withdrawal Syndrome / drug therapy, etiology* United States |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 439-14-5/Diazepam; 50-06-6/Phenobarbital; 846-49-1/Lorazepam; 96-48-0/4-Butyrolactone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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