Document Detail

A case with insulinoma diagnosed and localized preoperatively using contrast-enhanced ultrasonography (CEUS) and arterial stimulation and venous sampling (ASVS).
MedLine Citation:
PMID:  16543684     Owner:  NLM     Status:  MEDLINE    
We report a case with insulinoma diagnosed and localized preoperatively using a combination of contrast-enhanced ultrasonography (CEUS) and arterial stimulation and venous sampling (ASVS). A 76-year-old woman was admitted to our hospital because of hypoglycemic attacks, delirium, and dementia. Fajans' ratio, Grunt's ratio, and Turner's ratio, which are reported to be indexes for endogenous hyperinsulinemia in insulinoma, were all negative. Imaging tests, including computed tomography, magnetic resonance imaging and angiography, failed to detect any abnormalities. CEUS showed a small low echoic lesion in the pancreatic body with blood flow and ASVS showed that the insulin levels in the hepatic vein were extremely increased by calcium injection to the splenic artery, indicating an insulinoma in the pancreatic body preoperatively. An open intra-abdominal operation was performed and an insulinoma was confirmed in the pancreatic body. Enucleation of tumor was undertaken and symptomatic hypoglycemia improved.
Taro Horino; Toshihiro Takao; Kozo Hashimoto
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Endocrine journal     Volume:  53     ISSN:  0918-8959     ISO Abbreviation:  Endocr. J.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-03-17     Completed Date:  2006-06-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  141-6     Citation Subset:  IM    
Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Japan.
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MeSH Terms
Angiography / methods*
Blood Specimen Collection
Calcium / administration & dosage,  diagnostic use
Hypoglycemia / surgery
Injections, Intra-Arterial
Injections, Intravenous
Insulinoma / blood supply*,  pathology,  surgery,  ultrasonography*
Magnetic Resonance Imaging
Pancreatic Neoplasms / blood supply*,  pathology,  surgery,  ultrasonography*
Regional Blood Flow
Ultrasonography / methods*
Reg. No./Substance:

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