Document Detail


A case of virilizing adrenocortical carcinoma.
MedLine Citation:
PMID:  2834927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 36-year-old woman who had experienced two pregnancies consulted our hospital, because of scant menses and virilization. A 24-hour excretion of 17-ketosteroids and 17-hydroxy-corticosteroids demonstrated a decrease in 11-hydroxylase. A computed tomogram showed a huge inhomogenous tumefaction in the left adrenal. Left selective renal angiography revealed a large adrenal tumefaction. Selective adrenal venous samplings revealed that testosterone and dehydroepiandrosterone (DHA) were produced in response to stimulation by 0.25 mg exogenous adrenocorticotropic hormone (ACTH). After left adrenalectomy was performed, a diagnosis of adrenocortical carcinoma was made by pathological examination. This is the first report of a patient with a virilizing adrenocortical carcinoma, which produced testosterone and DHA in response to exogenous ACTH stimulation.
Authors:
H Takiuchi; T Oka; M Namiki; Y Ichikawa; T Sonoda; M Koga; B Sato; S Onishi; T Nakamura; H Matsushita
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Hinyokika kiyo. Acta urologica Japonica     Volume:  33     ISSN:  0018-1994     ISO Abbreviation:  Hinyokika Kiyo     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-06-07     Completed Date:  1988-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421145     Medline TA:  Hinyokika Kiyo     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  2090-4     Citation Subset:  IM    
Affiliation:
Department of Urology, Osaka University Hospital.
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MeSH Terms
Descriptor/Qualifier:
17-Hydroxycorticosteroids / urine
17-Ketosteroids / urine
Adrenal Cortex Neoplasms / diagnosis*,  pathology
Adrenocorticotropic Hormone / diagnostic use
Adult
Carcinoma / diagnosis*,  pathology
Dehydroepiandrosterone / blood
Female
Humans
Testosterone / blood
Tomography, X-Ray Computed
Virilism*
Chemical
Reg. No./Substance:
0/17-Hydroxycorticosteroids; 0/17-Ketosteroids; 53-43-0/Dehydroepiandrosterone; 58-22-0/Testosterone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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