| A case of ulcerative colitis accompanied with myelodysplastic syndrome successfully treated by cyclosporine. | |
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MedLine Citation:
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PMID: 21817844 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A 64-year-old man had been admitted to a previous hospital because of melena and a diagnosis of ulcerative colitis (UC, pancolitis type) had been made. He had received prednisolone and 5-ASA but steroid-induced hyperamylasemia had developed. Prednisolone had been tapered and halted, but it had resulted in UC relapse and thrombocytopenia. Then, he was referred to our hospital due to severe melena with hypovolemic shock. However, he was also positive for CMV antigen. Thus, we attempted to treat him with ganciclovir for CMV and intravenous cyclosporine (CsA) for UC. According to his clinical course, a reduction of CsA blood concentration induced leukocytopenia. Myelodysplastic syndrome (MDS, RAEB-1) was then revealed after bone marrow biopsy. A high blood CsA concentration may cause the improvement of UC and MDS conditions. |
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Authors:
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Sho Takahashi; Yasushi Sato; Tamotsu Sagawa; Shingo Tanaka; Kazuyuki Murase; Kohichi Takada; Satoshi Iyama; Tsutomu Sato; Rishu Takimoto; Masayoshi Kobune; Ganji Kuroiwa; Michiaki Hirayama; Tetsuro Okamoto; Junji Kato |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology Volume: 108 ISSN: 1349-7693 ISO Abbreviation: Nihon Shokakibyo Gakkai Zasshi Publication Date: 2011 |
Date Detail:
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Created Date: 2011-08-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984683R Medline TA: Nihon Shokakibyo Gakkai Zasshi Country: Japan |
Other Details:
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Languages: eng Pagination: 1405-12 Citation Subset: IM |
Affiliation:
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Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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