Document Detail

A case of type F botulism in southern California.
MedLine Citation:
PMID:  15461246     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Botulism caused by type F botulinum toxin accounts for less than 0.1% of all human botulism cases and is rarely reported in the literature. CASE REPORT: A 45-year-old woman presented to an emergency department complaining of blurred vision, difficulty focusing, and dysphagia. The treating physician initially considered the possibility of paralytic shellfish poisoning due to a report of shellfish ingestion, which was later determined to be frozen shrimp and a can of tuna, but no gastroenteritis or paresthesias were present. During the emergency department observation, the patient developed respiratory distress with hypercapnea and required intubation and mechanical ventilation. Within hours, ptosis, mydriasis, and weakness in the arms and legs developed. Bivalent (A, B) botulinum antitoxin was administered approximately 24 h from the onset of initial symptoms, but over the next two days complete paralysis progressed to the upper and lower extremities. Shortly thereafter a stool toxin assay demonstrated the presence of type F botulinum toxin. The patient subsequently received an experimental heptavalent botulinum antitoxin on hospital day 7 but paralysis was already complete. Her three-week hospital course was complicated by nosocomial pneumonia and a urinary tract infection, but she gradually improved and was discharged to a rehabilitation facility. Anaerobic cultures and toxin assays have yet to elucidate the source of exposure. CONCLUSION: We report a rare case of type F botulism believed to be foodborne in etiology. Administration of bivalent botulinum antitoxin did not halt progression of paralysis.
William H Richardson; Shermane S Frei; Saralyn R Williams
Related Documents :
7949506 - Adverse interaction between clonidine and verapamil.
21119256 - Primary bone lymphoma: a report of two cases and review of the literature.
12954706 - Tension pneumothorax: eyes may be more diagnostic than ears.
760536 - Pelvic actinomycosis in women using intrauterine contraceptive devices.
10808626 - Systemic necrotizing vasculitis: a review, with the personal perspective of a nurse edu...
15459816 - Chlamydial infection preceding the development of rheumatoid arthritis: a brief report.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of toxicology. Clinical toxicology     Volume:  42     ISSN:  0731-3810     ISO Abbreviation:  J. Toxicol. Clin. Toxicol.     Publication Date:  2004  
Date Detail:
Created Date:  2004-10-05     Completed Date:  2004-10-15     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8213460     Medline TA:  J Toxicol Clin Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  383-7     Citation Subset:  AIM; IM    
California Poison Control System, San Diego Division, San Diego, California, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Botulinum Antitoxin / administration & dosage
Botulinum Toxins / poisoning*
Botulism / diagnosis*,  pathology,  therapy
Diagnosis, Differential
Emergency Treatment
Middle Aged
Respiration, Artificial
Shellfish Poisoning*
Reg. No./Substance:
0/Botulinum Antitoxin; 0/Botulinum Toxins; 0/botulinum toxin type F

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Drug identification: a survey of poison control centers.
Next Document:  Effects of pyrethroids on tyrosine hydroxylase in nigrostriatum of male rats