Document Detail

A case of transfusion-associated graft-versus-host disease not prevented by white cell-reduction filters.
MedLine Citation:
PMID:  1542924     Owner:  NLM     Status:  MEDLINE    
A case of transfusion-associated graft-versus-host disease (TA-GVHD) in a patient with non-Hodgkin's lymphoma is reported. The patient, a 67-year-old woman, was diagnosed as having diffuse, mixed type non-Hodgkin's lymphoma, at clinical stage IIIA. She was treated with combination chemotherapy and received multiple blood transfusions for anemia and thrombocytopenia. Although white cells (WBCs) were reduced in the transfused components by WBC-reduction filters, the patient developed TA-GVHD that was confirmed by skin biopsy. It is suggested that the WBC reduction attained with these filters does not prevent TA-GVHD in immunocompromised patients. It is recommended that all blood components should be irradiated before transfusion to such patients.
M Akahoshi; M Takanashi; M Masuda; H Yamashita; A Hidano; K Hasegawa; T Kasajima; M Shimizu; T Motoji; K Oshimi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Transfusion     Volume:  32     ISSN:  0041-1132     ISO Abbreviation:  Transfusion     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-04-07     Completed Date:  1992-04-07     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  169-72     Citation Subset:  IM    
Department of Hematology, Tokyo Women's Medical College, Japan.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Blood Transfusion / adverse effects*
Bone Marrow / pathology
Cell Separation
Graft vs Host Disease / etiology*,  prevention & control
Hemoglobins / analysis
Leukocyte Count*
Leukocytes / pathology
Lymphoma, Non-Hodgkin / blood,  drug therapy,  pathology,  therapy*
Platelet Count*
Reg. No./Substance:

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