| A case of transfusion-associated graft-versus-host disease not prevented by white cell-reduction filters. | |
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MedLine Citation:
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PMID: 1542924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A case of transfusion-associated graft-versus-host disease (TA-GVHD) in a patient with non-Hodgkin's lymphoma is reported. The patient, a 67-year-old woman, was diagnosed as having diffuse, mixed type non-Hodgkin's lymphoma, at clinical stage IIIA. She was treated with combination chemotherapy and received multiple blood transfusions for anemia and thrombocytopenia. Although white cells (WBCs) were reduced in the transfused components by WBC-reduction filters, the patient developed TA-GVHD that was confirmed by skin biopsy. It is suggested that the WBC reduction attained with these filters does not prevent TA-GVHD in immunocompromised patients. It is recommended that all blood components should be irradiated before transfusion to such patients. |
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Authors:
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M Akahoshi; M Takanashi; M Masuda; H Yamashita; A Hidano; K Hasegawa; T Kasajima; M Shimizu; T Motoji; K Oshimi |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Transfusion Volume: 32 ISSN: 0041-1132 ISO Abbreviation: Transfusion Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-04-07 Completed Date: 1992-04-07 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 0417360 Medline TA: Transfusion Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 169-72 Citation Subset: IM |
Affiliation:
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Department of Hematology, Tokyo Women's Medical College, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Blood Transfusion / adverse effects* Bone Marrow / pathology Cell Separation Female Graft vs Host Disease / etiology*, prevention & control Hemoglobins / analysis Humans Leukocyte Count* Leukocytes / pathology Lymphoma, Non-Hodgkin / blood, drug therapy, pathology, therapy* Platelet Count* |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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