| A case of systemic-onset juvenile idiopathic arthritis complicated with sepsis -Usefulness of cytokine profile for the differentiation between macrophage activation syndrome and sepsis-. | |
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MedLine Citation:
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PMID: 21628853 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The differential diagnosis of macrophage activation syndrome (MAS) and sepsis must be considered in the clinical course of systemic-onset juvenile idiopathic arthritis (s-JIA) with sudden onset of high-grade fever and abnormal laboratory findings, including leukocytopenia, thrombocytopenia, and coagulopathy. In this report, we describe the case of a 17-month-old girl diagnosed with s-JIA complicated with sepsis. Her serum interleukin (IL)-18 level was significantly elevated throughout the clinical course. Furthermore, compared to other MAS patients, she showed a significantly elevated serum IL-6 level and procalcitonin in sepsis. Therefore, our results suggest that a patient's cytokine profile may be a useful indicator of disease activity and may thus help in the differential diagnosis of sepsis and MAS in s-JIA. |
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Authors:
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Tadafumi Yokoyama; Masaki Shimizu; Iku Ikeno; Yoko Hashida; Syuhei Fujita; Shoetu Shimura; Kiyoshi Hatasaki; Naohisa Shintani; Akihiro Yachie |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology Volume: 34 ISSN: 1349-7413 ISO Abbreviation: Nihon Rinsho Meneki Gakkai Kaishi Publication Date: 2011 |
Date Detail:
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Created Date: 2011-06-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505992 Medline TA: Nihon Rinsho Meneki Gakkai Kaishi Country: Japan |
Other Details:
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Languages: eng Pagination: 105-11 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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