Document Detail


A case study of validation and sample analysis for the determination of zotarolimus in various tissues.
MedLine Citation:
PMID:  23534425     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background: Biodistribution of drug and drug candidates offers critical information regarding drug disposition in target and nontarget tissues. Concentrations of therapeutic agents in target tissue provide the foundation for efficacy, while concentrations in nontarget tissue pose potential safety risks. Analysis of tissue samples can sometimes provide important information during the development of a drug candidate, especially at early stages when radio labeled drug material is not readily available. Results: Determining the appropriate approach to allow for accurate, precise and reproducible drug concentration measurements from tissue samples requires addressing issues not present in routinely analyzed biological matrices, that is, plasma. We present here the issues encountered and techniques applied during the development, validation and application of a method for the determination of zotarolimus in a variety of tissues. Conclusion: When well controlled, analysis of tissue samples can be performed in a manner similar to liquid biological matrices.
Authors:
M Todd Reimer; Xia Wan; Jun Zhang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioanalysis     Volume:  5     ISSN:  1757-6199     ISO Abbreviation:  Bioanalysis     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101512484     Medline TA:  Bioanalysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  811-7     Citation Subset:  IM    
Affiliation:
AbbVie, Dept. R46W Bldg. AP13A, 1 N Waukegan Rd, North Chicago, IL 60064, USA.
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