Document Detail


A case study of trastuzumab treatment for metastatic breast cancer in pregnancy: fetal risks and management of cerebral metastases.
MedLine Citation:
PMID:  21806575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Trastuzumab increases survival amongst women with human epidermal growth factor receptor (HER)-2 receptor positive metastatic breast cancer, but maternal and fetal risks are associated with advanced disease and its treatment in pregnancy. We present a case of a primigravid with HER-2 positive metastatic breast cancer who received trastuzumab throughout pregnancy. She presented with cerebral metastases, requiring surgical decompression and resection. Reversible oligohydramnios developed during pregnancy. Fetal safety data on trastuzumab in pregnancy is limited, but case reports suggest a recurring pattern of (mostly reversible) oligohydramnios.
Authors:
Christine L Mandrawa; Josephine Stewart; Gavin C Fabinyi; Susan P Walker
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-05-12
Journal Detail:
Title:  The Australian & New Zealand journal of obstetrics & gynaecology     Volume:  51     ISSN:  1479-828X     ISO Abbreviation:  Aust N Z J Obstet Gynaecol     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-16     Completed Date:  2012-01-10     Revised Date:  2013-05-08    
Medline Journal Info:
Nlm Unique ID:  0001027     Medline TA:  Aust N Z J Obstet Gynaecol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  372-6     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Australian and New Zealand Journal of Obstetrics and Gynaecology © 2011 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.
Affiliation:
University Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Victoria, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Monoclonal, Humanized / administration & dosage*
Antineoplastic Agents / administration & dosage*
Bone Neoplasms / drug therapy,  secondary
Brain Neoplasms / metabolism,  secondary,  surgery*
Breast Neoplasms / drug therapy*,  metabolism,  pathology
Carcinoma, Ductal, Breast / drug therapy*,  metabolism,  secondary
Craniotomy
Decompression, Surgical
Female
Humans
Immunohistochemistry
Infant, Newborn
Liver Neoplasms / drug therapy,  secondary
Magnetic Resonance Imaging
Male
Oligohydramnios / etiology,  physiopathology
Pregnancy
Pregnancy Complications, Neoplastic*
Pregnancy Outcome
Radiosurgery
Receptor, erbB-2 / metabolism*
Risk Factors
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal, Humanized; 0/Antineoplastic Agents; EC 2.7.10.1/Receptor, erbB-2; P188ANX8CK/trastuzumab

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