Document Detail

A case study of the applicability of a prediction model for the selection of patients undergoing in vitro fertilization for single embryo transfer in another center.
MedLine Citation:
PMID:  17307175     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the application in a different fertility clinic of a prediction model for selecting IVF patients for elective single embryo transfer. DESIGN: Retrospective analysis of a large database obtained from a tertiary infertility center. SETTING: University medical center. PATIENT(S): The model, derived at the "development center" was applied in 494 consecutive first IVF cycles carried out at the "application center." INTERVENTION(S): After adjustment of embryo scoring system to be compatible with that used by the prediction model, it was applied to the development center data. A score chart for predicting the probability of singleton or twin pregnancy was constructed. MAIN OUTCOME MEASURE(S): The area under the receiver operator curve (ROC) was determined to measure the ability of the model to discriminate between ongoing pregnancy and twin pregnancy. Calibration plots were made to assess agreement between predicted and observed pregnancy rates (PR). RESULTS: The areas under the ROC for predicting ongoing pregnancy and twin pregnancy were 0.63 and 0.66, respectively. Insertion of a correction factor equivalent to the difference in odds ratios for ongoing PR between the two centers was required to improve the calibration of the model. CONCLUSION(S): After adaptation, the model performed well in the application center.
Claudine C Hunault; Egbert R te Velde; Sjerp M Weima; Nicholas S Macklon; Marinus J C Eijkemans; Ellen R Klinkert; J Dik F Habbema
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Publication Detail:
Type:  Journal Article     Date:  2007-02-20
Journal Detail:
Title:  Fertility and sterility     Volume:  87     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-04     Completed Date:  2007-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1314-21     Citation Subset:  IM    
Department of Public Health, Erasmus MC University, Medical Center Rotterdam, Rotterdam, The Netherlands. <>
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MeSH Terms
Embryo Transfer*
Embryonic Development
Fertilization in Vitro*
Patient Selection
Predictive Value of Tests
Pregnancy Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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